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  • Title: Isolation of two new polymyxin group antibiotics. (Studies on antibiotics from the genus Bacillus. XX).
    Author: Shoji J, Hinoo H, Wakisaka Y, Koizumi K, Mayama M, Matsuura S.
    Journal: J Antibiot (Tokyo); 1977 Dec; 30(12):1029-34. PubMed ID: 202582.
    Abstract:
    Two new members of polymyxin group antibiotics, polymyxins S1 and T1, were isolated from the culture broths of strains identified as Bacillus polymyxa Rs-6 and Bacillus polymyxa E-12, respectively. These antibiotics are strongly basic substances, their hydrochloric acid salts are soluble in water and methanol. They are primarily active against Gram-negative bacteria in vitro and in vivo though polymyxin T1 exhibits higher activities against Gram-positive bacteria than other polymyxin group antibiotics.
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