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  • Title: [Plasma levels of beta-endorphin in obese subjects with normal glucose tolerance test and in diabetics].
    Author: Donatelli M, Terrizzi C, Russo V, Bucalo ML, Scarpinato A, Verga S, Puglisi S, Miceli G, Iraci T, Bompiani GD.
    Journal: Recenti Prog Med; 1991 Jan; 82(1):1-3. PubMed ID: 2028070.
    Abstract:
    Forty obese subjects with normal glucose tolerance test (NGTT) thirteen diabetic obese subjects and sixteen normal subjects were studied to evaluate the possible interactions between beta-endorphin (B-Ep) and glucose homeostasis. On the basis of baseline B-Ep levels, two subgroups were selected: one group with normal mean values of B-Ep (7.02 +/- 0.59 pmol/l); another group with elevated mean values of B-Ep (18.95 +/- 1.52 pmol/l). No differences between these subgroups were found as regards body mass index (BMI), insulin and glucagon levels. Normal B-Ep values were found in diabetic obese subjects. No significant correlation was found between B-Ep and BMI, insulin or glucagon. Considering that B-Ep is involved in eating behavior and on the basis of our results, we suggest that elevated B-Ep levels can be found only in those obese NGTT subjects whose obesity is probably related to an abnormal modulation of food intake, such as hyperphagia.
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