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Pubmed for Handhelds

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  • Title: Synthesis of a steroidal A ring aromatic sulfonic acid as an inhibitor of steroid 5 alpha-reductase.
    Author: Holt DA, Oh HJ, Levy MA, Metcalf BW.
    Journal: Steroids; 1991 Jan; 56(1):4-7. PubMed ID: 2028482.
    Abstract:
    The synthesis of 17 beta-(N,N-diisopropylcarbamoyl)estra-1,3,5(10)-triene-3-sulfonic acid (3) has been accomplished. Sulfonate 3 was designed as a novel inhibitor of human steroid 5 alpha-reductase based on considerations of enzyme mechanisms, and exhibits an inhibition constant in the low nanomolar range.
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