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  • Title: [Guidance for the treatment of neovascular age-related macular degeneration (AMD)].
    Author: Karska-Basta I, Kubicka-Trzaska A, Oleksy P, Romanowska-Dixon B.
    Journal: Przegl Lek; 2009; 66(11):972-5. PubMed ID: 20297641.
    Abstract:
    BACKGROUND: Neovascular age-related macular degeneration (AMD) is becoming an increasing socio-medical problem as the proportion of the aged population is continuously increasing. However, new researches in the pathogenesis of the disease offer the opportunity to develop more effective therapies of AMD. AIM: This article will focus on the options in the management of neovascular age-related macular degeneration and recent therapeutic options. RESULTS: The recent development of anti-VEGF (vascular endothelial growth factor) substances for use in clinical routine has markedly improved the prognosis of patients with neovascular AMD. Intravitreal treatment with substances targeting all isotypes of Vascular Endothelial Growth Factor (VEGF), for the first time results in a significant increase in visual acuity in patients with neovascular AMD. The combination with occlusive therapies like photodynamic therapy (PDT) potentially offers a reduction of re-treatment frequency and long-term maintenance of the treatment benefit. Further developments interacting with various steps in the angiogenic cascade are under clinical or preclinical evaluation and may soon become available. CONCLUSION: Nevertheless, the growing number of novel therapeutic options will have to provide proof of concept in randomized controlled clinical trials.
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