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  • Title: [Reversible thrombocytopenia and polyneuropathy: the pleiotropic aspects of hypothyroidism].
    Author: Woei-A-Jin FJ, van Breemen MS, Brand A, Brouwer RE.
    Journal: Ned Tijdschr Geneeskd; 2010; 154():A963. PubMed ID: 20298634.
    Abstract:
    Although the relationship between hyperthyroidism and thrombocytopenia is well documented, the relationship between hypothyroidism and thrombocytopenia is less well known. We describe a 69-year-old man with severe hypothyroidism, mild thrombocytopenia and sensorimotor axonal polyneuropathy. After thyroid hormone replacement therapy, he became euthyroid and his platelet count normalized over a period of three months. The thrombocytopenia may have been due to an immunomodulatory effect of thyroid-stimulating hormone (TSH). His neurological complaints disappeared and even though electromyography still showed signs of axonal polyneuropathy, nerve conduction velocities normalized and he had signs of re-innervation. Our case clearly demonstrates that hypothyroidism is a heterogeneous disease. As symptoms may be reversible with thyroid hormone replacement therapy, it should not be overlooked.
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