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  • Title: Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats.
    Author: Kovács Z, Czurkó A, Kékesi KA, Juhász G.
    Journal: Epilepsy Res; 2010 Jun; 90(1-2):167-70. PubMed ID: 20299188.
    Abstract:
    PURPOSE: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. METHODS: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4h after injection. The changes in SWDs were compared to the preceding 5-day average control level. RESULTS: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. CONCLUSIONS: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.
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