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  • Title: Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals.
    Author: Yuan K, Qin W, Dong M, Liu J, Liu P, Zhang Y, Sun J, Wang W, Wang Y, Li Q, Yang W, Tian J.
    Journal: Neurosci Lett; 2010 May 07; 475(1):20-4. PubMed ID: 20302912.
    Abstract:
    Majority of previous heroin fMRI studies focused on abnormal brain function in heroin-dependent individuals. However, few fMRI studies focused on the resting-state abnormalities in heroin-dependent individuals and assessed the relationship between the resting-state functional connectivity changes and duration of heroin use. In the present study, discrete cosine transform (DCT) was employed to explore spatial distribution of low frequency BOLD oscillations in heroin-dependent individuals and healthy subjects during resting-state; meanwhile resting-state functional connectivity analysis was used to investigate the temporal signatures of overlapping brain regions obtained in DCT analysis among these two groups. Main finding of the present study is that the default mode network (DMN) and rostral anterior cingulate cortex (rACC) network of heroin-dependent individuals were changed compared with healthy subjects. More importantly, these changes negatively correlated with duration of heroin use. These resting-state functional abnormalities in heroin-dependent individuals provided evidence for abnormal functional organization in heroin-dependent individuals, such as functional impairments in decision-making and inhibitory control.
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