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  • Title: Association of angiotensin converting enzyme gene insertion/deletion polymorphism with lung cancer in Turkey.
    Author: Nacak M, Nacak I, Sanli M, Ozkur M, Pektaş M, Aynacioğlu AS.
    Journal: Cancer Genet Cytogenet; 2010 Apr 01; 198(1):22-6. PubMed ID: 20303010.
    Abstract:
    Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. We investigated an insertion/deletion (I/D) polymorphism of the gene for ACE in relation to cardiovascular, cerebrovascular, neurodegenerative, and inflammatory diseases. The purpose of the present study was to investigate a possible association between lung cancer and insertion/deletion polymorphism of the ACE gene. A total of 125 patients with lung cancer and 165 control subjects were enrolled in the present study. ACE I/D genotypes were determined by polymerase chain reaction. Allelic frequencies and genotype distribution of the ACE I/D polymorphism in the patient group were significantly different from control subjects (ACE II genotype 29.6 vs. 17.6%, P = 0.011; ACE I allele 49.6 vs. 39.4%, P =0.009). Our data suggest that the ACE I/D polymorphism could be a risk factor for patients with lung cancer.
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