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  • Title: A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma.
    Author: Basile JR, Lin YL.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Apr; 109(4):e28-33. PubMed ID: 20303043.
    Abstract:
    The microcystic adnexal carcinoma (MAC) is a rare, slow-growing but locally aggressive neoplasm arising in the midface and lips of middle-aged adults. The MAC is histologically characterized by deeply infiltrating nests and islands of basaloid or squamous cells forming cysts and ductal structures, proliferating in a dense sclerotic stroma and occasionally exhibiting perineural invasion. We describe a salivary gland adenocarcinoma arising in the lower lip, characterized by ductal structures and cords, 3-5 cell layers in thickness, set in a dense fibrous stroma and also invading nerves, thus mimicking a MAC in both its clinical and its histopathologic appearance. The diagnostic dilemma presented by this lesion is discussed, along with a differential diagnosis and brief review of the literature.
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