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  • Title: Aberrant DNA methylation of imprinted H19 gene in human preimplantation embryos.
    Author: Chen SL, Shi XY, Zheng HY, Wu FR, Luo C.
    Journal: Fertil Steril; 2010 Nov; 94(6):2356-8, 2358.e1. PubMed ID: 20303482.
    Abstract:
    DNA methylation patterns of the H19 differentially methylated region were successfully determined in 32 of 50 human day 3 embryos produced and discarded after assisted reproductive technology procedures. We found methylation patterns similar to those of somatic cells in 81.3% of embryos and demethylation or hypomethylation patterns in 18.7% of embryos.
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