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  • Title: Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain.
    Author: Silva MG, Ueti MW, Norimine J, Florin-Christensen M, Bastos RG, Goff WL, Brown WC, Oliva A, Suarez CE.
    Journal: Parasitol Int; 2010 Jun; 59(2):294-7. PubMed ID: 20304092.
    Abstract:
    A gene coding for a protein with sequence similarity to the Toxoplasma gondii micronemal 1 (MIC1) protein that contains a copy of a domain described as a sialic acid-binding micronemal adhesive repeat (MAR) was identified in the Babesia bovis genome. The single copy gene, located in chromosome 3, contains an open reading frame encoding a putative 181 amino acid protein, which is highly conserved among distinct B. bovis strains. Antibodies against both recombinant protein and synthetic peptides mimicking putative antigenic regions in the B. bovis-MIC1 (Bbo-MIC1) protein bind to the parasite in immunofluorescence assays and significantly inhibit erythrocyte invasion in in vitro B. bovis cultures. Bbo-MIC1 is recognized by antibodies in serum from B. bovis infected cattle, demonstrating expression and immunogenicity during infection. Overall, the results suggest that Bbo-MIC1 protein is a viable candidate for development of subunit vaccines.
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