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  • Title: HLA-D typing with an association of Dw2 and absent immune responses towards herpes simplex (type i) antigen in multiple sclerosis.
    Author: Paty DW, Cousin HK, Stiller CR, Boucher DW, Furesz J, Warren KG, Marchuk L, Dossetor JB.
    Journal: Transplant Proc; 1977 Dec; 9(4):1845-8. PubMed ID: 203060.
    Abstract:
    We have confirmed that HLA-Dw2 is increased in MS patients to 47% (normals 20%). Lymphocyte transformation and antibody studies with herpes simplex antigen show that many of the DW2-positive MS patients have low or absent responses. The association of low responses to HSV and the presence of Dw2 is statistically significant at a p value less than 0.01.
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