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  • Title: From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones.
    Author: Lodish H, Flygare J, Chou S.
    Journal: IUBMB Life; 2010 Jul; 62(7):492-6. PubMed ID: 20306512.
    Abstract:
    This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages.
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