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  • Title: [Detection of the preservative chlorphenesin in cosmetics by high-performance liquid chromatography].
    Author: Ikarashi Y, Miyazawa N, Shimamura K, Sato N, Yoshizawa K, Hayashi M, Takano K, Miyamoto M, Kojima T, Sakaguchi H, Fujiio M.
    Journal: Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku; 2009; (127):50-3. PubMed ID: 20306707.
    Abstract:
    A simple determination method for preservative chlorphenesin in cosmetics was developed. Cosmetic samples were dissolved in methanol. The sample solution was analyzed by high-performance liquid chromatography (HPLC) with ODS column, using water-methanol (55:45) or water-acetonitrile (3:1) adjusted to pH 2.5 with phosphoric acid as the mobile phase. Chlorphenesin was detected with ultraviolet light detection at 280 nm. A linear relation was obtained between the peak areas and the concentrations of chlorphenesin in the range of 1-500 microg/ml. The determination limit of chlorphenesin was 1-2 microg/ml. Recoveries of chlorphenesin spiked in lotion and milky lotion at the levels of 0.03% and 0.3% were 98.8-100.0%. This method was applied for cosmetics including 0.03% and 0.3% of chlorphenesin and their content corresponded with the determined values.
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