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  • Title: A rabbit model of conjunctival injection induction after strabismus surgery enhanced by topical application of irritant chemicals.
    Author: Kim MJ, Hwang JM.
    Journal: Ophthalmic Surg Lasers Imaging; 2010; 41(2):261-5. PubMed ID: 20307047.
    Abstract:
    BACKGROUND AND OBJECTIVE: To establish a rabbit model of conjunctival injection after strabismus surgery. MATERIALS AND METHODS: A prospective, masked-observer, controlled study was performed. Twenty eyes of 20 rabbits underwent strabismus surgery. Fifteen eyes were treated with 90% ethanol for 5 minutes followed by dispase for 10 minutes and 5 eyes were treated with balanced salt solution as a control group. Injection severity was assessed by means of a grade (0 to 3) at 5 minutes, 1, 24, and 48 hours, and 1 week after surgery. RESULTS: The application of 90% ethanol for 5 minutes followed by dispase for 10 minutes reliably caused conjunctival injection in all of the rabbits and the injection scores were significantly higher than those of the control group at 24 (P = .008) and 48 (P = .001) hours and 1 week (P = .022) after surgery. CONCLUSION: The combined application of 90% ethanol and dispase in rabbit eyes was found to successfully create a conjunctival injection rabbit model after strabismus surgery.
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