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  • Title: Genotoxic and cell-transforming properties of (trans,trans)-muconaldehyde.
    Author: Henschler D, Eder E, Epe B, Schiffmann D.
    Journal: Mutat Res; 1991 May; 248(1):35-43. PubMed ID: 2030711.
    Abstract:
    (trans,trans)-Muconaldehyde, a putative metabolite of benzene, should be expected to have mutagenic properties by virtue of its twin alpha,beta-unsaturated carbonylic function. It displayed definitely mutagenic properties in S. typhimurium TA100 without metabolic activation and with a 5-fold concentration of tester organisms in the preincubation assay and induced SOS response in E. coli. It induced micronucleus formation and morphological transformation in a dose-dependent manner in Syrian hamster embryofibroblasts. No DNA single-strand breaks or interstrand cross-links could be detected using the alkaline elution technique; however, strand-break generation by subsequent gamma-irradiation was found to be increased.
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