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  • Title: Epithelial healing in experimental corneal alkali wounds with nondiluted autologous serum eye drops.
    Author: Salman IA, Gündoğdu C.
    Journal: Cutan Ocul Toxicol; 2010 Jun; 29(2):116-21. PubMed ID: 20307150.
    Abstract:
    PURPOSE: To evaluate the effects of the topical application of nondiluted autologous serum on epithelial healing as an adjuvant therapy in rabbit corneal alkali wounds. METHODS: Central corneal alkali wounds were produced on the right eye of 16 rabbits, by a 60-second application of a 6-mm round filter paper soaked in 1 N sodium hydroxide (NaOH). One group of rabbits (n=8) was treated with non-diluted autologous serum, the other control group (n=8) was treated with physiologic saline, topically 4 times a day. The epithelial healing of the wounds was followed on a slit lamp with and without fluorescein staining daily for 1 week. On day 7, both corneas of each rabbit were excised and assessed histopathologically. RESULTS: A significant increase in the epithelial healing rate was observed in the autologous serum-treated corneas compared with the controls. Epithelial hyperplasia was noticed in specimens with thickened surface cells with multilayers, revealing disorganization in both groups. The autologous serum-treated epithelium showed a relatively well-organized appearance. CONCLUSION: Nondiluted autologous serum eye drops could be used as an adjuvant therapy for promoting the epithelial healing process during the repair stage of corneal alkali wounds.
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