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  • Title: Inhibition of L-type calcium currents by salusin-beta in rat cardiac ventricular myocytes.
    Author: Shi JS, Li D, Li N, Lin L, Yang YJ, Tang Y, Sun T, Yuan WJ, Ren AJ.
    Journal: Peptides; 2010 Jun; 31(6):1146-9. PubMed ID: 20307603.
    Abstract:
    Salusin-beta is a new regulatory peptide relevant to the cardiovascular system and exerts negative inotropic effect on ventricular muscle. The purpose of the present study was to determine whether salusin-beta can inhibit cardiac L-type calcium channel current (I(Ca,L)). Using whole-cell voltage-clamp techniques, I(Ca,L) was measured in ventricular myocytes isolated from 12 to 16 weeks rats. Salusin-beta dose-dependently and reversibly reduced the magnitude of I(Ca,L) in rat ventricular myocytes. Neither threshold potential nor the peak potential of current-voltage relationship was affected. Salusin-beta increased the rate of I(Ca,L) inactivation without altering its gating properties. These results suggest salusin-beta inhibited I(Ca,L) by increasing the rate of I(Ca,L) inactivation and the inhibition of L-type Ca(2+) channels induced by salusin-beta may contribute to its negative inotropic effect on ventricular muscle.
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