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  • Title: Smoking and AMH levels in women with normal reproductive history.
    Author: Dafopoulos A, Dafopoulos K, Georgoulias P, Galazios G, Limberis V, Tsikouras P, Koutlaki N, Maroulis G.
    Journal: Arch Gynecol Obstet; 2010 Aug; 282(2):215-9. PubMed ID: 20309569.
    Abstract:
    PURPOSE: To investigate the effect of age and smoking on the AMH levels in normal cycling healthy women with normal reproductive history. MATERIALS AND METHODS: In 137 women, blood samples were taken on day 3 of a spontaneous cycle. Serum FSH, LH, E2, progesterone and AMH were measured in all blood samples. For the statistical analysis of the data, t test, Pearson's correlation and linear regression analysis were performed. RESULTS: Of 137 women (43%), 59 were smokers. Age was positively correlated with serum FSH and LH levels (r = 0.584, P < 0.001 and r = 0.330, P < 0.001, respectively) and negatively correlated with serum AMH levels (r = -0.882, P < 0.001). There were no significant differences in FSH, LH, E2, progesterone and AMH levels between smokers and non-smokers. Multiple stepwise linear regression analysis showed that in both smokers and non-smokers, age was the most significant determinant of AMH levels (r = -0.889, P < 0.001 and r = -0.944, P < 0.001, respectively), while smoking was not related to AMH levels. CONCLUSIONS: Aging significantly decreases AMH levels in women with normal cycles and normal reproductive history, while smoking does not seem to have significant effects on AMH levels.
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