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  • Title: IgA-containing immune complexes in the circulation of patients with primary Sjögren's syndrome.
    Author: Bendaoud B, Pennec YL, Lelong A, Le Noac'h JF, Magadur G, Jouquan J, Youinou P.
    Journal: J Autoimmun; 1991 Feb; 4(1):177-84. PubMed ID: 2031660.
    Abstract:
    IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum IgA and elevated levels of IgA with rheumatoid factor (RF) activity. IgA-CIC and IgA-RF were more frequent (P less than 0.03 and less than 0.001) in the 27 primary SS patients with, than in the 25 without extraglandular manifestations. IgA-CIC could play a role in mediating the tissue injury associated with primary SS.
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