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  • Title: [Identification of HBV infection in HBsAg-negative chronic active hepatitis with polymerase chain reaction].
    Author: Luo KX, Zhou R, Liang ZS.
    Journal: Zhonghua Nei Ke Za Zhi; 1991 Jan; 30(1):21-3, 60. PubMed ID: 2032490.
    Abstract:
    To explore the etiological agent(s) of HBsAg negative chronic active hepatitis, serum HBV DNA was tested in thirty-six of such cases with polymerase chain reaction. In total, viral DNA was detected in 24 cases (67%), including 11 of the 12 cases with positive anti-HBc alone, four of the nine cases with positive anti-HBs and nine of the 15 cases without any HBV markers. The results suggest that in cases of HBsAg-negative chronic active hepatitis, the etiology may still be hepatitis B virus, especially in cases with positive anti-HBc. Furthermore, the cause of activated histology might be due to viral replication.
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