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  • Title: Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic.
    Author: Uramoto M, Kim CJ, Shin-Ya K, Kusakabe H, Isono K, Phillips DR, McCloskey JA.
    Journal: J Antibiot (Tokyo); 1991 Apr; 44(4):375-81. PubMed ID: 2032945.
    Abstract:
    A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. 1H, 13C and 31P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 micrograms/ml.
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