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  • Title: Dowling-Degos disease: case report and review of the literature.
    Author: Batycka-Baran A, Baran W, Hryncewicz-Gwozdz A, Burgdorf W.
    Journal: Dermatology; 2010; 220(3):254-8. PubMed ID: 20332593.
    Abstract:
    Dowling-Degos disease (DDD) is an unusual pigmentary disorder usually caused by mutations in keratin 5. A 44-year-old woman in good general health presented due to the recent appearance of numerous pigmented macules on her axillary and anogenital skin. A biopsy showed lacy, finger-like epidermal extensions into the dermis which were heavily pigmented and associated with tiny cysts or dilated follicles. We view DDD as part of a spectrum of disorders which are morphologically related but vary in location and time of expression. In addition, both the clinical and histological differential diagnostic considerations are extensive.
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