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  • Title: Identification of a cis-acting positive regulatory element of the glial fibrillary acidic protein gene.
    Author: Sarid J.
    Journal: J Neurosci Res; 1991 Feb; 28(2):217-28. PubMed ID: 2033651.
    Abstract:
    Developmental regulation of astrocyte-specific expression of the glial fibrillary acidic protein (GFAP) gene reflects transition of immature glioblasts to mature astrocytes. Described here is the cloning and sequencing of the 5'-flanking region of the mouse GFAP gene. It contains a glial-specific positive cis-acting regulatory element that directs preferential expression of a linked reporter gene when transfected into GFAP-positive glioblastoma cells. Sequence analysis of this region revealed the presence of a putative AP-1 binding site, implying a possible role for AP-1 factors in the astroglial-specific expression of the GFAP gene.
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