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  • Title: [Peritoneal structural injury in laparoscopic versus open radical resection for colorectal cancer: a prospective controlled study].
    Author: Zhao BY, Li GX, Wang YN, Hu YF, He W, Yu J.
    Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Mar; 13(3):193-6. PubMed ID: 20336537.
    Abstract:
    OBJECTIVE: To assess the differences in peritoneal microstructure injury between laparoscopic and open radical resection for colorectal cancer. METHODS: A total of 50 patients with colorectal cancer were consecutively assigned into laparoscopic group (LO, n=27) and conventional laparotomy group (CO, n=23). Prospectively comparative analyses of operative time, intraoperative blood loss, number of lymph node harvest, positive rate of lymph nodes, length of specimen and resection margin involvement were performed. Optical microscope and scanning electron microscope were used to detect postoperative peritoneal injury between patients who received laparoscopic surgery or open surgery. RESULTS: Compared with the CO group, operative time [(150.6+/-39.5) min vs (183.0+/-39.2) min, P<0.05] and intraoperative blood loss [(80.0+/-75.2) ml vs (234.5+/-235.3) ml, P<0.01] were significantly less in the LO group. No significant differences were found between two groups in length specimen, number of lymph nodes harvest, positive rate of lymph nodes, and all resection margins were negative (P>0.05). Optical microscope indicated less serosal injury in the LO group as compared to the CO group with regard to serosal integrity, continuity of covering adipocyte and mesothelial cell, and the aggregation level of erythrocytes and inflammatory cells (P<0.01). Scanning electronic microscopy showed more severe injury to colorectal serosa, mesothelium and basement membrane in the CO group as compared to the LO group. CONCLUSION: With equal degree of radical resection, laparoscopic technique for colorectal cancer causes less peritoneal structural injury as compared with open surgery.
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