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  • Title: [The effects of hypoxic-ischemia on glutamate transporters].
    Author: Zeng W, Qu Y, Mao M.
    Journal: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2010 Feb; 27(1):202-5. PubMed ID: 20337054.
    Abstract:
    Glutamate is a kind of excitatory transmitter in the central nervous system of mammals; at the same time, being with excitatory toxicity, its extracellular concentration is mainly modulated by the glutamate transporters. In the case of hypoxic-ischemia, the energy failure would lead to the generation of lactate and free radical, and to the crash of [Na+] gradient, thus exerting influence on the activity and the expression of glutamate transporters. As a result, the glutamate accumulates in the synaptic cleft, activates the glutamate receptors, and causes the death of neurons.
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