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  • Title: Day-to-day reproducibility of prolonged ambulatory colonic manometry in healthy subjects.
    Author: Rao SS, Singh S, Mudipalli R.
    Journal: Neurogastroenterol Motil; 2010 Jun; 22(6):640-e178. PubMed ID: 20345373.
    Abstract:
    BACKGROUND: Although colonic manometry provides useful information regarding colonic physiology, considerable variability has been reported both for regional motility and manometric patterns. Whether colonic manometry is reproducible is not known. METHODS: Seven healthy volunteers (three men, four women, mean age = 34 years) underwent two studies of 24-h ambulatory colonic manometry, each 2 weeks apart. Manometry was performed by placing a six-sensor solid-state probe, up to the hepatic flexure and anchored to colonic mucosa. Colonic motility was assessed by the number and area-under-curve (AUC) of pressure waves and motility patterns such as high-amplitude propagating contractions (HAPC). Waking and meal-induced gastrocolonic responses were also assessed. Paired t-test was used to examine the reproducibility and intra and interindividual variability. KEY RESULTS: The number of pressure waves and propagating pressure waves and HAPC, and AUC were similar between the two studies. Diurnal variation, waking and meal-induced gastrocolonic responses were also reproducible. There was some variability in the incidence of individual colonic motor patterns. CONCLUSIONS & INFERENCES: Colonic manometry findings were generally reproducible, particularly for the assessment of key physiologic changes, such as meal-induced gastrocolonic, HAPC, and waking responses.
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