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Title: Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. Author: Xu H, Wang JJ. Journal: Bioorg Med Chem Lett; 2010 Apr 15; 20(8):2500-2. PubMed ID: 20346661. Abstract: In an attempt to find the effective phytopesticides, eight novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1mg/mL. Among all of the tested analogs, compounds 5a, 5c, 5d, and 5h showed the higher insecticidal activity than 4-deoxypodophyllotoxin. Especially 5a exhibited the most potent insecticidal activity compared with toosendanin, a commercial insecticide derived from Melia azedarach.[Abstract] [Full Text] [Related] [New Search]