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  • Title: Variation in composition of the intervillous space lining in term placentas of mothers with pre-eclampsia.
    Author: Hottor B, Bosio P, Waugh J, Diggle PJ, Byrne S, Ahenkorah J, Ockleford CD.
    Journal: Placenta; 2010 May; 31(5):409-17. PubMed ID: 20347142.
    Abstract:
    OBJECTIVE(S): To define composition of chorionic plate and test effects of pre-eclampsia on basal plate composition. STUDY DESIGN: Retrospective cohort study where distinct area fractions were measured in: healthy term chorionic plate (CP: n = 11), healthy placental basal plate (n = 11), mild pre-eclamptic basal plate (n = 10) and severe pre-eclamptic basal plate (n = 11). RESULTS: CP lining is partly endothelial. Mean anchoring villus (AV)/acellular (NS) basal plate area ratio decreased in pre-eclampsia (p = 0.048). There was a decreasing trend with increasing disease severity. Basal plate endothelial cell proportion was not significantly lower in severe pre-eclampsia than in healthy or mild pre-eclamptics. CONCLUSION(S): An inverse relationship between the proportions of fibrin and anchoring villi indicates that increased basal plate fibrin deposition and reduced basal plate materno-fetal anchoring area are part of pre-eclamptic disease progression. Endothelium lining intervillous surfaces may originate from circulating maternal endothelial progenitor cells.
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