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  • Title: Glutamatergic synaptic transmission in neuroendocrine cells: Basic principles and mechanisms of plasticity.
    Author: Iremonger KJ, Benediktsson AM, Bains JS.
    Journal: Front Neuroendocrinol; 2010 Jul; 31(3):296-306. PubMed ID: 20347860.
    Abstract:
    Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus that serve as the last step in synaptic integration before neurohormone release. While these synapses exhibit many similarities with other glutamate synapses described throughout the brain, they also exhibit a number of unique properties that are particularly well suited to the physiology of this system and will be discussed here. In addition, a number of recent studies begin to provide insights into new forms of synaptic plasticity that may be common in other brain regions, but in these cells, may serve important adaptive roles.
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