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  • Title: [Pharmacokinetics of biological tags in a case of acute valpromide self poisoning].
    Author: Commandeur D, Danguy Des Deserts M, Giacardi C, Eyrieux S, Ould-Ahmed M, Drouillard I.
    Journal: Ann Biol Clin (Paris); 2010; 68(2):234-8. PubMed ID: 20348051.
    Abstract:
    We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ventilation. An acidosis (pH = 7.24), a hyperlactatemia (2.72 mmol/L), a hyperammonemia (328.9 micromol/L), and were diagnosed valproic acid plasmatic concentration was 1190 microg/mL at 22 hours. Symptomatic treatment and L-carnitine therapy (50 mg/kg/12h) normalized the action of biological abnormalities and allowed disappearance of symptoms; the patient was extubated after 46 hours, and outcome from intensive care unit at 65 hours.
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