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  • Title: [Antiradiation properties of radioprotectors, immunomodulators and agents affecting tissue metabolism in fractionated irradiation].
    Author: Vasin MV, Chernov IuN, Semenova LA.
    Journal: Radiobiologiia; 1991; 31(2):271-5. PubMed ID: 2034808.
    Abstract:
    A comparative study was made of the protective efficacy of the per os administered cystamine and mexamine as well as of immunomodulators: decaris and thymoptin, and agents influencing tissue metabolism, such as glutamevite and phosphate concentrate, in conditions of fractionated gamma irradiation at a time interval between fractions of 7 to 1 days. In experiments with (CBA X C57B1/6)F1 and (DBA X C57B1/6)F1 hybrid mice it was shown that with a single exposure cystamine and mexamine protected 40-50% of animals. With a three-fold exposure once a week the efficacy of cystamine was as high as 70%. With exposure every other day the radioprotective efficacy of cystamine and mexamine dropped down to 28.3%. With daily exposure, cystamine was ineffective. Decaris and phosphate concentrate had a slight and transient effect amounting to 10-20%.
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