These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Glutathione-mediated response to acid stress in the probiotic bacterium, Lactobacillus salivarius.
    Author: Lee K, Pi K, Kim EB, Rho BS, Kang SK, Lee HG, Choi YJ.
    Journal: Biotechnol Lett; 2010 Jul; 32(7):969-72. PubMed ID: 20349113.
    Abstract:
    Lactobacillus salivarius, a probiotic bacterium, encounters acidic conditions in its passage through the gastrointestinal tract of human and animal hosts. We studied the effect of a rapid downshift in extracellular pH from 6.5 to 4 on cell growth. The maximum growth rate was higher in low pH medium with glutathione supplementation than without. Cells developed a GSH-mediated acid-tolerance response and, when grown with 0.5 mM GSH, reached a higher final density than with other conditions. These findings suggest that the increased growth rate is caused by uptake of GSH which acts as a nutrient source as well as having protective functions, allowing for continued growth.
    [Abstract] [Full Text] [Related] [New Search]