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  • Title: Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides.
    Author: Hueting R, Christlieb M, Dilworth JR, García Garayoa E, Gouverneur V, Jones MW, Maes V, Schibli R, Sun X, Tourwé DA.
    Journal: Dalton Trans; 2010 Apr 21; 39(15):3620-32. PubMed ID: 20354615.
    Abstract:
    A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both (64)Cu and (99m)Tc. Conjugation to a bombesin derivative was achieved using standard solid phase synthetic methodologies and the (64)Cu-labeled conjugate was shown to have good tumour uptake in mice with xenografted PC-3 tumours.
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