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  • Title: Human papillomavirus genotypes distribution in cervical samples from women living with human immunodeficiency virus.
    Author: Melgaço FG, Rosa ML, Augusto EF, Haimuri JG, Jacintho C, Santos LS, Cavalcanti SM, Oliveira LH.
    Journal: Arch Gynecol Obstet; 2011 Apr; 283(4):809-17. PubMed ID: 20354708.
    Abstract:
    BACKGROUND: The aim of this study was to determine the prevalence and relationship of human papillomavirus (HPV) genotypes in cervical samples from 140 human immunodeficiency virus (HIV)-seropositive women routinely attending an outpatient public gynecological service in the state of Rio de Janeiro, Brazil. METHODS: MY09/11 consensus primers were used to detect generic HPV DNA. HPV typification was performed by restriction fragment length polymorphism analysis following polymerase chain reaction amplification. RESULTS: The overall HPV prevalence was 60.0%. The identification of 24 different HPV genotypes including uncommon types was performed. A9 oncogenic genotypes were present in 54.02% of HIV-positive women. Abnormal cervical lesions, the time since HIV diagnosis and the number of sexual partners contributed independently to the high oncogenic HPV prevalence. The oncogenic and non-oncogenic group were similarly affected by risk factors in contrast to negative HPV women. The frequency of multiple infections was 20%; furthermore, all of them presented at least one oncogenic type. CONCLUSION: The analyzed sample represents an epidemiological source of uncommon infection. Due to high HPV prevalence, more frequent cytological screening and/or liberal colposcopic evaluations should be performed in HIV-positive patients.
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