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  • Title: Anti-Müllerian hormone (AMH): regulator and marker of ovarian function.
    Author: van Houten EL, Themmen AP, Visser JA.
    Journal: Ann Endocrinol (Paris); 2010 May; 71(3):191-7. PubMed ID: 20362961.
    Abstract:
    In this review, the role of anti-Müllerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS).
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