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  • Title: Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions.
    Author: Prajapati D, Bhuyan D, Gohain M, Hu W.
    Journal: Mol Divers; 2011 Feb; 15(1):257-61. PubMed ID: 20364370.
    Abstract:
    Iodine catalyzes the pseudo four-component reaction of an aldehyde, a urea or thiourea, and cyclic 1,3-dicarbonyl compounds under microwave irradiation in a solvent-free condition to yield various σ symmetric spiro heterobicyclic rings in excellent yields.
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