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  • Title: [Comparative study of resistance to acycloguanosine and acycloguanosine H-phosphonate in herpes simplex virus].
    Author: Andronova VL, Galegov GA, Ias'ko MV, Kukhanova MK, Skoblov IuS.
    Journal: Vopr Virusol; 2010; 55(1):31-4. PubMed ID: 20364669.
    Abstract:
    The ability of acycloguanosine H-phosphate to inhibit the reproduction of herpes simplex virus type 1 (HSV-1) variants, including its acycloguanosine (acyclovir)-resistant ones, was studied. Acycloguanosine H-phosphate-resistant HSV-1 variants were obtained. It was found that these variants were cross-resistant to thymidine kinase-dependent HSV reproduction inhibitors, but preserved sensitivity to Apa-A and phosphonoacetic acid.
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