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  • Title: Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplex DNA aptamer.
    Author: Ochsenkühn MA, Campbell CJ.
    Journal: Chem Commun (Camb); 2010 Apr 28; 46(16):2799-801. PubMed ID: 20369187.
    Abstract:
    We demonstrate a strategy for label-free protein detection through monitoring the Surface Enhanced Raman Spectrum of an aptamer probe attached to a gold nanoshell. Low limit of detection and minimal non-specific binding show potential for in vitro and in vivo assays.
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