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  • Title: [Pathomorphological assessment of renal biopsy specimens: principles and directions for clinicians].
    Author: Wagrowska-Danilewicz M, Niemir ZI.
    Journal: Pol Merkur Lekarski; 2010 Jan; 28(163):61-5. PubMed ID: 20369728.
    Abstract:
    The renal biopsy is a principal diagnostic method to provide information on type, activity and the intensity of the disease. The aim of the article is to describe the handling, fixation and processing of the renal tissue in pathomorphological laboratories, as well as to provide any information about histopathological glomerular lesions observed in glomerulopathies. The assessment of the renal biopsies includes light microscopy, immunofluorescence microscopy and electron microscopy. In each case clinicians should provide information on the patient's clinical history and recent laboratory values. Immunomorphological evaluation of the renal biopsy specimen should be done in all cases. In view of the high cost of the electron microscopy it seems that the best solution is to preserve the renal tissue in epon and provide ultrastructural evaluation according to the clinical data and light microscopy and immunofluorescence findings. The diagnosis of glomerulopathies requires a close cooperation between clinicians and pathologists. Pathologists should have access to clinical data, and clinicians should understand the limitations of the pathomorphological techniques.
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