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  • Title: Effect of losartan on vascular function in fructose-fed rats: the role of perivascular adipose tissue.
    Author: Huang F, Lezama MA, Ontiveros JA, Bravo G, Villafaña S, del-Rio-Navarro BE, Hong E.
    Journal: Clin Exp Hypertens; 2010 Jan; 32(2):98-104. PubMed ID: 20374189.
    Abstract:
    Recent studies have shown the effect of perivascular adipose tissue (PVAT) on the regulation of vascular function; however, its role in the model of metabolic syndrome remains unclear. The aim of this study was to examine the effect of losartan on PVAT-derived vascular dysfunction in fructose-induced hypertensive rats. Rats were fed with either water, 10% fructose, or 10% fructose with 10mg/kg losartan for 8 weeks. In the isolated aorta with PVAT and endothelium, contraction induced by norepinephrine (NE) was more potent in fructose-fed rats compared to control rats. Losartan normalized blood pressure, insulin resistance, and NE-induced vasoconstriction in fructose-fed rats. In the aortic rings with/without endothelium and with/without PVAT, losartan could not improve the acetylcholine-induced relaxation in fructose-fed rats. The observation suggested that losartan partly improved the PVAT-associated vascular regulation in fructose-induced hypertensive rats.
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