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  • Title: Pd-catalyzed C-N bond formation with heteroaromatic tosylates.
    Author: Mantel ML, Lindhardt AT, Lupp D, Skrydstrup T.
    Journal: Chemistry; 2010 May 10; 16(18):5437-42. PubMed ID: 20376827.
    Abstract:
    A protocol for the palladium(0)-catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodology proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon-nitrogen bond formation with these heteroaryl tosylates could be performed with a wide range of primary amides, oxazolidinones, lactams, anilines and indoles, including one cyclic urea. Moreover, this C-N bond forming reaction provided products with high structural diversity. The coupling reaction was also amenable to scale up applications.
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