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  • Title: KDR Kinase Inhibitor Isolated from the Mushroom Boletopsis leucomelas.
    Author: Kaneko A, Tsukada M, Fukai M, Suzuki T, Nishio K, Miki K, Kinoshita K, Takahashi K, Koyama K.
    Journal: J Nat Prod; 2010 May 28; 73(5):1002-4. PubMed ID: 20380423.
    Abstract:
    Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4-7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1-7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC(50) value of 70.7 microM. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC(50) value of 9.04 microM.
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