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  • Title: [Phenylhexyl isothiocyanate (PHI) regulates histone methylation and acetylation and induces apoptosis in SMMC-7721 cells].
    Author: Huang YQ, Ma XD, Lai YD, Wang XZ, Chiao JW, Liu DL.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2010 Mar; 18(3):209-12. PubMed ID: 20380799.
    Abstract:
    OBJECTIVE: To investigate the effects of PHI on histone acetylation and methylation in hepatocellular carcinoma line SMMC-7721 cells. METHODS: Apoptosis was measured by TUNNEL assay. Histone methylation and acetylation were detected by Western blot. RESULTS: PHI inhibited cells growth and induced apoptosis. PHI treatment resulted in increased acetylation of histone H3 and H4 , elevated level of histone H3 lysine 4 methylation, and decreased level of histone H3 lysine 9 methylation. CONCLUSIONS: PHI can modulate both histone acetylation and methylation, which could remodel chromatin structure. PHI may be a novel anticancer drug.
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