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  • Title: [Short-term treatment of thrombosis of heart valve prostheses with high doses of streptokinase. Presentation of 5 cases].
    Author: Souto JC, Zuazu-Jausoro I, Mateo J, Borrás X, Fontcuberta J.
    Journal: Med Clin (Barc); 1991 Feb 23; 96(7):261-4. PubMed ID: 2038221.
    Abstract:
    Five cases of thrombosis of cardiac prosthetic valves were treated with high dose fibrinolytic drugs during a short period of time. There were 3 mitral, one tricuspid and one pulmonary prosthetic valves. In 3 cases the treatment was successful without significant complications. Another patient, a woman in early pregnancy, died shortly after the treatment. The last patient required surgery as the cause of valve obstruction was a fibrous pannus virtually without thrombus formation. This diagnosis was intraoperative. The reported therapeutic modality permits a rapid resolution of valve obstruction. If this is not the case, surgery may be immediately carried out when the hemodynamic condition of the patient is still adequate.
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