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  • Title: EMS-induced dominant lethal dose response curve in DBA/1J male mice.
    Author: Favor J, Crenshaw JW.
    Journal: Mutat Res; 1978 Feb; 53(1):21-7. PubMed ID: 203848.
    Abstract:
    An ethyl methanesulfonate (EMS) induced dominant lethal dose response experiment was conducted in strain DBA/1J male mice. Two methods of scoring for dominant lethals, the classic method (dissecting females at mid-pregnancy) and an alternative method (inspection of uterine scars after litters were weaned) were compared. Results indicate that strain DBA/1J has a similar sensitivity to EMS-induced dominant lethals as has been previously reported for other mouse genotypes. Of the two methods used to score dominant lethals, the classic method is more sensitive.
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