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  • Title: Alkaloids from roots of Stephania rotunda and their cholinesterase inhibitory activity.
    Author: Hung TM, Dang NH, Kim JC, Jang HS, Ryoo SW, Lee JH, Choi JS, Bae K, Min BS.
    Journal: Planta Med; 2010 Oct; 76(15):1762-4. PubMed ID: 20391319.
    Abstract:
    In the course of screening plants used in folk medicine as memory enhancers, a 70% ethanolic extract of Stephania rotunda roots showed significant AChE inhibitory activity. Repeated column chromatography led to the isolation of a new protoberberine alkaloid, which we named stepharotudine (1), and seven known compounds (2-8). The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. Compounds 1-8 were investigated in vitro for their anticholinesterase activity using a rat cortex AChE enzyme.
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