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  • Title: Pretreatment with remifentanil is associated with less succinylcholine-induced fasciculation.
    Author: Nasseri K, Arastheh MT, Shami S.
    Journal: Middle East J Anaesthesiol; 2010 Feb; 20(4):515-9. PubMed ID: 20394247.
    Abstract:
    BACKGROUND: Succinylcholine is a popular muscle relaxant and one of its most common side effects is muscle fasciculation. The purpose of this study was to evaluate the efficacy of remifentanil in preventing succinylcholine-induced fasciculation in patients undergoing general anesthesia. METHODS: In aprospective, double blind study, 60 ASA I & II patients were randomly assigned into two groups (30 each) to receive either remifentanil 1 microg/kg (Group R), or saline 3 ml (Group S) as a pretreatment agent, one minute before induction of general anesthesia by propofol, fentanyl, and 1.5 mg/kg succinylcholine. The duration and the intensity of fasciculation were assessed using a four-point rating scale. Data were analyzed by Mann-Whitney U-test, Fisher exact test and Student-t-test using SPSS software. RESULTS: In the remifentanil group the duration (p < 0.001) and the intensity (p < 0.001) of fasciculation were lower compared to the saline group. However the incidence of bradycardia was higher in the remifentanil group in comparison to the group which received normal saline. CONCLUSIONS: Our findings indicate that remifentanil can reduce the duration and the intensity of succinylcholine induced fasciculation. However, it induces greater bradycardia.
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