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  • Title: Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor.
    Author: Horton JE, Wezeman FH, Kuettner KE.
    Journal: Science; 1978 Mar 24; 199(4335):1342-5. PubMed ID: 204011.
    Abstract:
    A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.
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