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  • Title: Towards click bioconjugations on cube-octameric silsesquioxane scaffolds.
    Author: Fabritz S, Heyl D, Bagutski V, Empting M, Rikowski E, Frauendorf H, Balog I, Fessner WD, Schneider JJ, Avrutina O, Kolmar H.
    Journal: Org Biomol Chem; 2010 May 07; 8(9):2212-8. PubMed ID: 20401398.
    Abstract:
    Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including the first effective conjugation with a fully unprotected functional peptide towards a POSS assembled peptide octamer.
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